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Dr. Ronnie H. Fang is currently an Assistant Project Scientist in the Department of NanoEngineering at the University of California, San Diego (UC San Diego). As a NanoEngineering graduate student and postdoctoral scholar under the mentorship of Dr. Liangfang Zhang at UC San Diego, he helped to pioneer the development of a new class of biomimetic nanoparticles that are disguised by natural cell membranes. Currently, Ronnie's goal is to find new and exciting medical applications for these membrane-coated nanoparticles with the goal of improving the overall quality of human health.
Education
Postdoc NanoEngineering, UC San Diego, 2015-2017 Ph.D. NanoEngineering, UC San Diego, 2014 M.S. NanoEngineering, UC San Diego, 2012 B.S. Engineering Physics, UC San Diego, 2011 Biochemistry & Cell Biology, UC San Diego, 2011 |
Research
My research focuses on leveraging biological membranes coated onto synthetic nanoparticle cores (synthesis depicted below) for the design of novel nanotherapeutics. These new biomimetic nanoparticles can be used to address many different medical problems, and my research specifically focuses three applications, including immunoengineering, nanodetoxification, and bio-interfacing/targeted delivery.
I) Immunoengineering
Nanoparticle technology offers exciting new prospects in the field of vaccine development. By designing the particles to carry both antigenic material as well as strong immunological adjuvants, it is possible to vaccine formulations capable of effecting diverse immune responses, including against cancer cells and bacterial toxins. Additionally, their small size allows for more efficient transport to lymphoid organs where the payloads can effect the maximal immune responses.
II) Nanodetoxification
Biomimetic nanoparticles coated in cell membranes retain all of the surface moieties present on the original cells. By taking advantage of the natural interactions that occur between many toxic molecules and compounds with cell membrane, biomimetic nanoparticles can act as effective decoys that bind and divert toxins away from their intended targets.
III) Biointerfacing and targeted delivery
Cell membranes have evolved over millions of years to perform specific functions, including site-specific binding and biological interfacing. By employing different types of cell membranes, it is possible to take advantage of the natural affinity and interactions exhibited by these cells to modulate particle localization.
Nanoparticle technology offers exciting new prospects in the field of vaccine development. By designing the particles to carry both antigenic material as well as strong immunological adjuvants, it is possible to vaccine formulations capable of effecting diverse immune responses, including against cancer cells and bacterial toxins. Additionally, their small size allows for more efficient transport to lymphoid organs where the payloads can effect the maximal immune responses.
II) Nanodetoxification
Biomimetic nanoparticles coated in cell membranes retain all of the surface moieties present on the original cells. By taking advantage of the natural interactions that occur between many toxic molecules and compounds with cell membrane, biomimetic nanoparticles can act as effective decoys that bind and divert toxins away from their intended targets.
III) Biointerfacing and targeted delivery
Cell membranes have evolved over millions of years to perform specific functions, including site-specific binding and biological interfacing. By employing different types of cell membranes, it is possible to take advantage of the natural affinity and interactions exhibited by these cells to modulate particle localization.
Publications
2019
79. Wierzbicki, I.; Campeau, A.; Dehaini, D.; Holay, M.; Wei, X.; Greene, T.; Ying, M.; Sands, J.; Lamsa, A.; Zuniga, E.; Pogliano, K.; Fang, R.H.; LaRock, C.; Zhang, L.; Gonzalez, D. "Group A streptococcal S protein utilizes red blood cells as immune camouflage and is a critical determinant for immune evasion", Cell Reports 2019, in press.
78. Zhou, J.; Kroll, A.; Holay, M.; Fang, R.H.*; Zhang, L.* "Biomimetic nanotechnology towards personalized vaccines", Advanced Materials 2019, in press. (*Co-corresponding author) Link
77. Park, J-H.; Dehaini, D.; Zhou, J.; Holay, M.; Fang, R.H.*; Zhang, L.* “Biomimetic nanoparticle technology for cardiovascular disease detection and treatment”, Nanoscale Horizons 2019, in press. (*Co-corresponding author) Link
76. Karshalev, E.; Zhang, Y.; Esteban-Fernández de Ávila, B.; Beltrán-Gastélum, M.; Chen, Y.; Mundaca-Uribe, R.; Zhang, F.; Nguyen, B.; Tong, Y.; Fang, R.H.; Zhang, L.; Wang, J. "Micromotors for active delivery of minerals toward the treatment of iron deficiency anemia", ACS Nano, 2019, 19, 7816-7826. Link
75. Zhang, F.; Zhuang, J.; Esteban-Fernández de Ávila, B.; Tang, S.; Zhang, Q.; Fang, R.H.; Zhang, L.; Wang, J. "A nanomotor-based active delivery system for intracellular oxygen transport", ACS Nano, 2019, 13, 11996-12005. Link
74. Zhuang, J.; Holay, M.; Park, J-H.; Fang, R.H.; Zhang, J.; Zhang, L. “Nanoparticle delivery of immunostimulatory agents for cancer immunotherapy”, Theranostics 2019, 9, 7826-7848. Link
73. Fang, R.H.*; Zhang, L.* "Biomimetic nanosponges as a broad-spectrum countermeasure to biological threats", HDIAC Journal, 2019, 6, 14-19. (*Co-corresponding author) Link
72. Zhang, Y.; Chen, Y.; Lo, C.; Zhuang, J.; Angsantikul, P.; Zhang, Q.; Wei, X.; Zhou, Z.; Obonyo, M.; Fang, R.H.; Gao, W.; Zhang, L. “Inhibition of pathogen adhesion by bacterial outer membrane-coated nanoparticles”, Angewandte Chemie International Edition 2019, 58, 11404-11408. Link
71. Wei, X.; Ran, D.; Campeau, A.; Xiao, C.; Zhou, J.; Dehaini, D.; Jiang, Y.; Zhang, Q.; Gao, W.; Gonzalez, D.; Fang, R.H.*; Zhang, L.* "Multiantigenic nanotoxoid for antivirulence vaccination against antibiotic-resistant gram-negative bacteria", Nano Letters 2019, 19, 4760-4769. (*Co-corresponding author) Link
70. Leong, H.S.; et al. "On the issue of transparency and reproducibility in nanomedicine", Nature Nanotechnology 2019, 14, 629-635. Link
69. Chen, Y.; Zhang, Y.; Zhuang, J.; Lee, J.H.; Wang, L.; Fang, R.H.; Gao, W.; Zhang, L. "Cell membrane-cloaked oil nanosponges enable dual-modal detoxification", ACS Nano 2019, 13, 7209-7215. Link
68. Chai, Z.; Ran, D.; Lu, L.; Zhan, C.; Ruan, H.; Hu, X.; Xie, C.; Jiang, K.; Li, J.; Zhou, J.; Wang, J.; Zhang, Y.; Fang, R.H.; Zhang, L.; Lu, W. "Ligand-modified cell membrane enables targeted delivery of drug nanocrystals to glioma", ACS Nano 2019, 13, 5591-5601. Link
67. Zhang, G.; Luk, B.T.; Wei, X.; Campbell, G.R.; Fang, R.H.; Zhang, L.; Spector, S.A. “Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides”, Cell Death & Disease 2019, 10, 419. Link
66. Gong, H.; Chen, F.; Huang, Z.; Gu, Y.; Zhang, Q.; Chen, Y.; Zhang, Y.; Zhuang, J.; Cho, Y.; Fang, R.H.; Gao, W.; Xu, S.; Zhang, L. "Biomembrane-modified field effect transistors for sensitive and quantitative detection of biological toxins and pathogens", ACS Nano 2019, 13, 3714-3722. Link
65. Wei, X.; Beltran-Gastelum, M.; Karshalev, E.; Bsteban-Fernandez de Avila, B.; Zhou, J.; Ran, D.; Angsantikul, P.; Fang, R.H.; Wang, J.; Zhang, L. "Biomimetic micromotor enables active delivery of antigens for oral vaccination", Nano Letters 2019, 19, 1914-1921. Link
64. Chen, Y.; Zhang, Y.; Chen, M.; Zhuang, J.; Fang, R.H.; Gao, W.; Zhang, L. “Biomimetic nanosponges suppress in vivo lethality induced by the whole secreted proteins of pathogenic bacteria”, Small 2019, 15, 1804994. Link
63. Kroll, A.V.; Jiang, Y.; Zhou, J.; Holay, M.; Fang, R.H.*; Zhang, L.* “Biomimetic nanoparticle vaccines for cancer therapy”, Advanced Biosystems 2018, 3, 1800219. (*Co-corresponding author) Link
62. Jiang, Y.; Chekuri, S.; Fang, R.H.*; Zhang, L.* “Engineering biological interactions at the nanoscale”, Current Opinion in Biotechnology 2019, 58, 1-8. (*Co-corresponding author) Link
78. Zhou, J.; Kroll, A.; Holay, M.; Fang, R.H.*; Zhang, L.* "Biomimetic nanotechnology towards personalized vaccines", Advanced Materials 2019, in press. (*Co-corresponding author) Link
77. Park, J-H.; Dehaini, D.; Zhou, J.; Holay, M.; Fang, R.H.*; Zhang, L.* “Biomimetic nanoparticle technology for cardiovascular disease detection and treatment”, Nanoscale Horizons 2019, in press. (*Co-corresponding author) Link
76. Karshalev, E.; Zhang, Y.; Esteban-Fernández de Ávila, B.; Beltrán-Gastélum, M.; Chen, Y.; Mundaca-Uribe, R.; Zhang, F.; Nguyen, B.; Tong, Y.; Fang, R.H.; Zhang, L.; Wang, J. "Micromotors for active delivery of minerals toward the treatment of iron deficiency anemia", ACS Nano, 2019, 19, 7816-7826. Link
75. Zhang, F.; Zhuang, J.; Esteban-Fernández de Ávila, B.; Tang, S.; Zhang, Q.; Fang, R.H.; Zhang, L.; Wang, J. "A nanomotor-based active delivery system for intracellular oxygen transport", ACS Nano, 2019, 13, 11996-12005. Link
74. Zhuang, J.; Holay, M.; Park, J-H.; Fang, R.H.; Zhang, J.; Zhang, L. “Nanoparticle delivery of immunostimulatory agents for cancer immunotherapy”, Theranostics 2019, 9, 7826-7848. Link
73. Fang, R.H.*; Zhang, L.* "Biomimetic nanosponges as a broad-spectrum countermeasure to biological threats", HDIAC Journal, 2019, 6, 14-19. (*Co-corresponding author) Link
72. Zhang, Y.; Chen, Y.; Lo, C.; Zhuang, J.; Angsantikul, P.; Zhang, Q.; Wei, X.; Zhou, Z.; Obonyo, M.; Fang, R.H.; Gao, W.; Zhang, L. “Inhibition of pathogen adhesion by bacterial outer membrane-coated nanoparticles”, Angewandte Chemie International Edition 2019, 58, 11404-11408. Link
71. Wei, X.; Ran, D.; Campeau, A.; Xiao, C.; Zhou, J.; Dehaini, D.; Jiang, Y.; Zhang, Q.; Gao, W.; Gonzalez, D.; Fang, R.H.*; Zhang, L.* "Multiantigenic nanotoxoid for antivirulence vaccination against antibiotic-resistant gram-negative bacteria", Nano Letters 2019, 19, 4760-4769. (*Co-corresponding author) Link
70. Leong, H.S.; et al. "On the issue of transparency and reproducibility in nanomedicine", Nature Nanotechnology 2019, 14, 629-635. Link
69. Chen, Y.; Zhang, Y.; Zhuang, J.; Lee, J.H.; Wang, L.; Fang, R.H.; Gao, W.; Zhang, L. "Cell membrane-cloaked oil nanosponges enable dual-modal detoxification", ACS Nano 2019, 13, 7209-7215. Link
68. Chai, Z.; Ran, D.; Lu, L.; Zhan, C.; Ruan, H.; Hu, X.; Xie, C.; Jiang, K.; Li, J.; Zhou, J.; Wang, J.; Zhang, Y.; Fang, R.H.; Zhang, L.; Lu, W. "Ligand-modified cell membrane enables targeted delivery of drug nanocrystals to glioma", ACS Nano 2019, 13, 5591-5601. Link
67. Zhang, G.; Luk, B.T.; Wei, X.; Campbell, G.R.; Fang, R.H.; Zhang, L.; Spector, S.A. “Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides”, Cell Death & Disease 2019, 10, 419. Link
66. Gong, H.; Chen, F.; Huang, Z.; Gu, Y.; Zhang, Q.; Chen, Y.; Zhang, Y.; Zhuang, J.; Cho, Y.; Fang, R.H.; Gao, W.; Xu, S.; Zhang, L. "Biomembrane-modified field effect transistors for sensitive and quantitative detection of biological toxins and pathogens", ACS Nano 2019, 13, 3714-3722. Link
65. Wei, X.; Beltran-Gastelum, M.; Karshalev, E.; Bsteban-Fernandez de Avila, B.; Zhou, J.; Ran, D.; Angsantikul, P.; Fang, R.H.; Wang, J.; Zhang, L. "Biomimetic micromotor enables active delivery of antigens for oral vaccination", Nano Letters 2019, 19, 1914-1921. Link
64. Chen, Y.; Zhang, Y.; Chen, M.; Zhuang, J.; Fang, R.H.; Gao, W.; Zhang, L. “Biomimetic nanosponges suppress in vivo lethality induced by the whole secreted proteins of pathogenic bacteria”, Small 2019, 15, 1804994. Link
63. Kroll, A.V.; Jiang, Y.; Zhou, J.; Holay, M.; Fang, R.H.*; Zhang, L.* “Biomimetic nanoparticle vaccines for cancer therapy”, Advanced Biosystems 2018, 3, 1800219. (*Co-corresponding author) Link
62. Jiang, Y.; Chekuri, S.; Fang, R.H.*; Zhang, L.* “Engineering biological interactions at the nanoscale”, Current Opinion in Biotechnology 2019, 58, 1-8. (*Co-corresponding author) Link
2018
61. Zhuang, J.; Ying, M.; Spiekermann, K.; Holay, M.; Zhang, Y.; Chen, F.; Gong, H.; Lee, J.H.; Gao, W.; Fang, R.H.; Zhang, L. "Biomimetic nanoemulsions for oxygen delivery in vivo", Advanced Materials 2018, 30, 1804693. Link
60. Zhang, Q.; Dehaini, D.; Zhang, Y.; Zhou, J.; Chen, X.; Zhang, L.; Fang, R.H.; Gao, W.; Zhang, L. "Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis", Nature Nanotechnology 2018, 13, 1182-1190. Link
59. Wei, X.; Zhang, G.; Ran, D.; Krishnan, N.; Fang, R.H.; Gao, W.; Spector, S.; Zhang, L. "T cell-mimicking nanoparticles can neutralize HIV infectivity", Advanced Materials 2018, 30, 1802233. Link
58. Luk, B.T.; Jiang, Y.; Copp, J.; Hu, C-M.; Krishnan, N.; Gao, W.; Li, S.; Fang, R.H.*; Zhang, L.* "Biomimetic targeting of nanoparticles to immune cell subsets via cognate antigen interactions", Molecular Pharmaceutics 2018, 15, 3723-3728. (*Co-corresponding author) Link
57. Xia, H.; Li, X.; Gao, W.; Fu, X.; Fang, R.H.; Zhang, L.; Zhang, K. “Tissue repair and regeneration with endogenous stem cells”, Nature Reviews Materials 2018, 3, 174-193. Link
56. Fang, R.H.*; Zhang, L.* “Combatting infections with nanomedicine”, Advanced Healthcare Materials 2018, 7, 1800392. (*Co-corresponding author) Link
55. Angsantikul, P.; Thamphiwatana, S.; Zhang, Q.; Spiekermann, K.; Zhuang, J.; Fang, R.H.; Gao, W.; Obonyo, M.; Zhang, L. “Coating nanoparticles with gastric epithelial cell membrane for targeted antibiotic delivery against Helicobacter pylori infection”, Advanced Therapeutics 2018, 1, 1800016. Link
54. Fang, R.H.; Kroll, A.V.; Gao, W.; Zhang, L. “Cell membrane coating nanotechnology”, Advanced Materials 2018, 30, 1706759. Link
53. Ying, M.; Zhuang, J.; Wei, X.; Zhang, X.; Zhang, Y.; Jiang, Y.; Dehaini, D.; Chen, M.; Gu, S.; Gao, W.; Lu, W.; Fang, R.H.; Zhang, L. “Remote-loaded platelet vesicles for disease-targeted delivery of therapeutics”, Advanced Functional Materials 2018, 28, 1801032. Link
52. Lapek, J.; Mills, R.; Wozniak, J.; Campeau, A.; Fang, R.H.; Wei, X.; van de Groep, K.; Perez-Lopez, A.; van Sorge, N.; Raffatellu, M.; Knight, R.; Zhang, L.; Gonzalez, D. "Defining host responses during systemic bacterial infection through construction of a murine organ proteome atlas", Cell Systems 2018, 6, 579-592. Link
51. Fang, R.H.; Zhang, L. “Optical detection of abnormal skin scarring”, Nature Biomedical Engineering 2018, 2, 201-202. Link
50. Jiang, Y.; Fang, R.H.*; Zhang, L.* "Biomimetic nanosponges for treating antibody-mediated autoimmune diseases", Bioconjugate Chemistry 2018, 29, 870-877. (*Co-corresponding author) Link
49. Chen, Y.; Chen, M.; Zhang, Y.; Lee, J. H.; Escajadillo, T.; Gong, H.; Fang, R.H.; Gao, W.; Nizet, V.; Zhang, L. "Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges", Advanced Healthcare Materials 2018, 7, 1701366. Link
48. Angsantikul, P.; Fang, R.H.*; Zhang, L.* “Toxoid vaccination against bacterial infection using cell membrane-coated nanoparticles”, Bioconjugate Chemistry 2018, 29, 604-612. (*Co-corresponding author) Link
47. Wei, X.; Ying, M.; Dehaini, D.; Su, Y.; Kroll, A.V.; Zhou, J.; Gao, W.; Fang, R.H.; Chien, S.; Zhang, L. “Nanoparticle functionalization with platelet membrane enables multifactored biological targeting and detection of atherosclerosis”, ACS Nano 2018, 12, 109-116. Link
60. Zhang, Q.; Dehaini, D.; Zhang, Y.; Zhou, J.; Chen, X.; Zhang, L.; Fang, R.H.; Gao, W.; Zhang, L. "Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis", Nature Nanotechnology 2018, 13, 1182-1190. Link
59. Wei, X.; Zhang, G.; Ran, D.; Krishnan, N.; Fang, R.H.; Gao, W.; Spector, S.; Zhang, L. "T cell-mimicking nanoparticles can neutralize HIV infectivity", Advanced Materials 2018, 30, 1802233. Link
58. Luk, B.T.; Jiang, Y.; Copp, J.; Hu, C-M.; Krishnan, N.; Gao, W.; Li, S.; Fang, R.H.*; Zhang, L.* "Biomimetic targeting of nanoparticles to immune cell subsets via cognate antigen interactions", Molecular Pharmaceutics 2018, 15, 3723-3728. (*Co-corresponding author) Link
57. Xia, H.; Li, X.; Gao, W.; Fu, X.; Fang, R.H.; Zhang, L.; Zhang, K. “Tissue repair and regeneration with endogenous stem cells”, Nature Reviews Materials 2018, 3, 174-193. Link
56. Fang, R.H.*; Zhang, L.* “Combatting infections with nanomedicine”, Advanced Healthcare Materials 2018, 7, 1800392. (*Co-corresponding author) Link
55. Angsantikul, P.; Thamphiwatana, S.; Zhang, Q.; Spiekermann, K.; Zhuang, J.; Fang, R.H.; Gao, W.; Obonyo, M.; Zhang, L. “Coating nanoparticles with gastric epithelial cell membrane for targeted antibiotic delivery against Helicobacter pylori infection”, Advanced Therapeutics 2018, 1, 1800016. Link
54. Fang, R.H.; Kroll, A.V.; Gao, W.; Zhang, L. “Cell membrane coating nanotechnology”, Advanced Materials 2018, 30, 1706759. Link
53. Ying, M.; Zhuang, J.; Wei, X.; Zhang, X.; Zhang, Y.; Jiang, Y.; Dehaini, D.; Chen, M.; Gu, S.; Gao, W.; Lu, W.; Fang, R.H.; Zhang, L. “Remote-loaded platelet vesicles for disease-targeted delivery of therapeutics”, Advanced Functional Materials 2018, 28, 1801032. Link
52. Lapek, J.; Mills, R.; Wozniak, J.; Campeau, A.; Fang, R.H.; Wei, X.; van de Groep, K.; Perez-Lopez, A.; van Sorge, N.; Raffatellu, M.; Knight, R.; Zhang, L.; Gonzalez, D. "Defining host responses during systemic bacterial infection through construction of a murine organ proteome atlas", Cell Systems 2018, 6, 579-592. Link
51. Fang, R.H.; Zhang, L. “Optical detection of abnormal skin scarring”, Nature Biomedical Engineering 2018, 2, 201-202. Link
50. Jiang, Y.; Fang, R.H.*; Zhang, L.* "Biomimetic nanosponges for treating antibody-mediated autoimmune diseases", Bioconjugate Chemistry 2018, 29, 870-877. (*Co-corresponding author) Link
49. Chen, Y.; Chen, M.; Zhang, Y.; Lee, J. H.; Escajadillo, T.; Gong, H.; Fang, R.H.; Gao, W.; Nizet, V.; Zhang, L. "Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges", Advanced Healthcare Materials 2018, 7, 1701366. Link
48. Angsantikul, P.; Fang, R.H.*; Zhang, L.* “Toxoid vaccination against bacterial infection using cell membrane-coated nanoparticles”, Bioconjugate Chemistry 2018, 29, 604-612. (*Co-corresponding author) Link
47. Wei, X.; Ying, M.; Dehaini, D.; Su, Y.; Kroll, A.V.; Zhou, J.; Gao, W.; Fang, R.H.; Chien, S.; Zhang, L. “Nanoparticle functionalization with platelet membrane enables multifactored biological targeting and detection of atherosclerosis”, ACS Nano 2018, 12, 109-116. Link
2017
46. Zhang, Y.; Gao, W.; Chen, Y.; Escajadillo, T.; Ungerleider, J.; Fang, R.H.; Christman, K.; Nizet, V.; Zhang, L. "Self-assembled colloidal gel using cell membrane-coated nanosponges as building blocks", ACS Nano 2017, 11, 11923-11930. Link
45. Lapek, J.D.; Fang, R.H.; Wei, X.; Li, P.; Wang, B.; Zhang, L.; Gonzalez, D.J. “Biomimetic virulomics for capture and identification of cell-type specific effector proteins”, ACS Nano 2017, 11, 11768-11772. Link
44. Kroll, A.V.*; Fang, R.H.*; Jiang, Y.; Zhou, J.; Wei, X.; Yu, C.L.; Gao, J.; Luk, B.T.; Dehaini, D.; Gao, W.; Zhang, L. “Nanoparticulate delivery of cancer cell membrane elicits multiantigenic antitumor immunity”, Advanced Materials 2017, 29, 1703969. (*Co-first author) Link
43. Zhang, X.; Angsantikul, P.; Ying, M.; Zhuang, J.; Zhang, Q.; Wei, X.; Jiang, Y.; Zhang, Y.; Dehaini, D.; Chen, M.; Chen, Y.; Gao, W.; Fang, R.H.; Zhang, L. “Remote loading of small molecule therapeutics into cholesterol-enriched cell membrane-derived vesicles”, Angewandte Chemie International Edition 2017, 56, 14075-14079. Link
42. Thamphiwatana, S.; Angsantikul, P.; Escajadillo, T.; Zhang, Q.; Olson, J.; Luk, B.T.; Zhang, S.; Fang, R.H.; Gao, W.; Nizet, V.; Zhang, L. “Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management”, Proceedings of the National Academy of Sciences 2017, 114, 11488-11493. Link
41. Chai, Z.; Hu, X.; Wei, X.; Zhan, C.; Lu, L.; Jiang, K.; Su, B.; Ruan, H.; Ran, D.; Fang, R.H.; Zhang, L.; Lu, W. "A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery", Journal of Controlled Release 2017, 264, 102-111. Link
40. Zhang, Y.; Zhang, J.; Chen, W.; Angsantikul, P.; Spiekermann, K.; Fang, R.H.; Gao, W.; Zhang, L. "Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection", Journal of Controlled Release 2017, 263, 185-191. Link
39. Zhuang, J.; Fang, R.H.; Zhang, L. "Preparation of particulate polymerics therapeutics for medical applications", Small Methods 2017, 1, 1700147. Link
38. Wei, X.; Gao, J.; Wang, F.; Ying, M.; Angsantikul, P.; Kroll, A.; Zhou, J.; Gao, W.; Lu, W.; Fang, R.H.; Zhang, L. "In situ capture of bacterial toxins for antivirulence vaccination", Advanced Materials 2017, 29, 1701644. Link
37. Dehaini, D.; Wei, X.; Fang, R.H.; Masson, S.; Angsantikul, P.; Luk, B.; Zhang, Y.; Ying, M.; Jiang, Y.; Kroll, A.; Gao, W.; Zhang, L. "Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization", Advanced Materials 2017, 29, 1606209. Link
36. Fang, R.H.; Jiang, Y.; Fang, J.; Zhang, L. "Cell membrane-derived nanomaterials for biomedical applications", Biomaterials 2017, 128, 69-83. Link
35. Kroll, A.; Fang, R.H.; Zhang, L. "Biointerfacing and applications of cell membrane-coated nanoparticles", Bioconjugate Chemistry 2017, 28, 23-32. Link
45. Lapek, J.D.; Fang, R.H.; Wei, X.; Li, P.; Wang, B.; Zhang, L.; Gonzalez, D.J. “Biomimetic virulomics for capture and identification of cell-type specific effector proteins”, ACS Nano 2017, 11, 11768-11772. Link
44. Kroll, A.V.*; Fang, R.H.*; Jiang, Y.; Zhou, J.; Wei, X.; Yu, C.L.; Gao, J.; Luk, B.T.; Dehaini, D.; Gao, W.; Zhang, L. “Nanoparticulate delivery of cancer cell membrane elicits multiantigenic antitumor immunity”, Advanced Materials 2017, 29, 1703969. (*Co-first author) Link
43. Zhang, X.; Angsantikul, P.; Ying, M.; Zhuang, J.; Zhang, Q.; Wei, X.; Jiang, Y.; Zhang, Y.; Dehaini, D.; Chen, M.; Chen, Y.; Gao, W.; Fang, R.H.; Zhang, L. “Remote loading of small molecule therapeutics into cholesterol-enriched cell membrane-derived vesicles”, Angewandte Chemie International Edition 2017, 56, 14075-14079. Link
42. Thamphiwatana, S.; Angsantikul, P.; Escajadillo, T.; Zhang, Q.; Olson, J.; Luk, B.T.; Zhang, S.; Fang, R.H.; Gao, W.; Nizet, V.; Zhang, L. “Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management”, Proceedings of the National Academy of Sciences 2017, 114, 11488-11493. Link
41. Chai, Z.; Hu, X.; Wei, X.; Zhan, C.; Lu, L.; Jiang, K.; Su, B.; Ruan, H.; Ran, D.; Fang, R.H.; Zhang, L.; Lu, W. "A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery", Journal of Controlled Release 2017, 264, 102-111. Link
40. Zhang, Y.; Zhang, J.; Chen, W.; Angsantikul, P.; Spiekermann, K.; Fang, R.H.; Gao, W.; Zhang, L. "Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection", Journal of Controlled Release 2017, 263, 185-191. Link
39. Zhuang, J.; Fang, R.H.; Zhang, L. "Preparation of particulate polymerics therapeutics for medical applications", Small Methods 2017, 1, 1700147. Link
38. Wei, X.; Gao, J.; Wang, F.; Ying, M.; Angsantikul, P.; Kroll, A.; Zhou, J.; Gao, W.; Lu, W.; Fang, R.H.; Zhang, L. "In situ capture of bacterial toxins for antivirulence vaccination", Advanced Materials 2017, 29, 1701644. Link
37. Dehaini, D.; Wei, X.; Fang, R.H.; Masson, S.; Angsantikul, P.; Luk, B.; Zhang, Y.; Ying, M.; Jiang, Y.; Kroll, A.; Gao, W.; Zhang, L. "Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization", Advanced Materials 2017, 29, 1606209. Link
36. Fang, R.H.; Jiang, Y.; Fang, J.; Zhang, L. "Cell membrane-derived nanomaterials for biomedical applications", Biomaterials 2017, 128, 69-83. Link
35. Kroll, A.; Fang, R.H.; Zhang, L. "Biointerfacing and applications of cell membrane-coated nanoparticles", Bioconjugate Chemistry 2017, 28, 23-32. Link
2016
34. Wei, X.; Gao, J.; Fang, R.H.; Luk, B.; Kroll, A.; Dehaini, D.; Zhou, J.; Kim, H. W.; Gao, W.; Lu, W.; Zhang, L. "Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia", Biomaterials 2016, 111, 116-123. Link
33. Dehaini, D.; Fang, R.H.; Luk, B.T.; Pang, Z.; Hu, C-M.; Kroll, A.; Yu, C.L.; Gao, W.; Zhang, L. "Ultra-small lipid-polymer hybrid nanoparticles for tumor-penetrating drug delivery", Nanoscale 2016, 8, 14411-14419. Link
32. Dehaini, D.; Fang, R.H.; Zhang, L. "Biomimetic strategies for targeted nanoparticle delivery", Bioengineering & Translational Medicine 2016, 1, 30-46. Link
31. Fang, R.H.; Zhang, L. "Nanoparticle-based modulation of the immune system", Annual Review of Chemical and Biomolecular Engineering 2016, 7, 305-326. Link
30. Chen, W.; Zhang, Q.; Luk, B.T.; Fang, R.H.; Liu, Y.; Gao, W.; Zhang, L. “Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function”, Nanoscale 2016, 8, 10364-10370. Link
29. Luk, B.T.; Fang, R.H.; Hu, C-M.; Copp, J.; Thamphiwatana, S.; Dehaini, D.; Gao, W.; Zhang, K.; Li, S.; Zhang, L. "Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors", Theranostics 2016, 6, 1004-1011. Link
28. Wang, F.; Fang, R.H.; Luk, B.T.; Hu, C-M.; Thamphiwatana, S.; Dehaini, D.; Angsantikul, P.; Kroll, A.; Pang, Z.; Gao, W.; Lu, W.; Zhang, L. "Nanoparticle-based anti-virulence vaccine for the management of methicillin-resistant Staphylococcus aureus skin infection", Advanced Functional Materials 2016, 26, 1628-1635. Link
33. Dehaini, D.; Fang, R.H.; Luk, B.T.; Pang, Z.; Hu, C-M.; Kroll, A.; Yu, C.L.; Gao, W.; Zhang, L. "Ultra-small lipid-polymer hybrid nanoparticles for tumor-penetrating drug delivery", Nanoscale 2016, 8, 14411-14419. Link
32. Dehaini, D.; Fang, R.H.; Zhang, L. "Biomimetic strategies for targeted nanoparticle delivery", Bioengineering & Translational Medicine 2016, 1, 30-46. Link
31. Fang, R.H.; Zhang, L. "Nanoparticle-based modulation of the immune system", Annual Review of Chemical and Biomolecular Engineering 2016, 7, 305-326. Link
30. Chen, W.; Zhang, Q.; Luk, B.T.; Fang, R.H.; Liu, Y.; Gao, W.; Zhang, L. “Coating nanofiber scaffolds with beta cell membrane to promote cell proliferation and function”, Nanoscale 2016, 8, 10364-10370. Link
29. Luk, B.T.; Fang, R.H.; Hu, C-M.; Copp, J.; Thamphiwatana, S.; Dehaini, D.; Gao, W.; Zhang, K.; Li, S.; Zhang, L. "Safe and immunocompatible nanocarriers cloaked in RBC membranes for drug delivery to treat solid tumors", Theranostics 2016, 6, 1004-1011. Link
28. Wang, F.; Fang, R.H.; Luk, B.T.; Hu, C-M.; Thamphiwatana, S.; Dehaini, D.; Angsantikul, P.; Kroll, A.; Pang, Z.; Gao, W.; Lu, W.; Zhang, L. "Nanoparticle-based anti-virulence vaccine for the management of methicillin-resistant Staphylococcus aureus skin infection", Advanced Functional Materials 2016, 26, 1628-1635. Link
2015
27. Fang, R.H.; Kroll, A.; Zhang, L. "Nanoparticle-based manipulation of antigen presenting cells for cancer immunotherapy", Small 2015, 11, 5483-5496. Link | Journal Cover
26. Hu, C-M.*; Fang, R.H.*; Wang, K-C.*; Luk, B.; Thamphiwatana, S.; Dehaini, D.; Nguyen, P.; Angsantikul, P.; Wen, C.; Kroll, A.; Carpenter, C.; Ramesh, M.; Qu, V.; Patel, S.; Zhu, J.; Shi, W.; Hofman, F.; Chen, T.; Gao, W; Zhang, K.; Chien, S.; Zhang, L. "Nanoparticle biointerfacing by platelet membrane cloaking", Nature 2015, 526, 118-121. (*Co-first author) Link
25. Zhang, J.; Gao, W.; Fang, R.H.; Dong, A.; Zhang, L. "Synthesis of nanogels via cell membrane-templated polymerization", Small 2015, 11, 4309-4313. Link
24. Fang, R.H.; Luk, B.; Hu, C-M.; Zhang, L. "Engineered nanoparticles mimicking cell membranes for toxin neutralization", Advanced Drug Delivery Reviews 2015, 90, 69-80. Link | Journal Cover
23. Pang, Z.; Hu, C-M. J.; Fang, R. H.; Luk, B. T.; Gao, W.; Wang, F.; Chuluun, E.; Angsantikul, P.; Thamphiwatana, S.; Lu, W.; Jiang, X.; Zhang, L. "Detoxification of organophosphate poisoning using nanoparticle bioscavengers", ACS Nano 2015, 9, 6450-6458. Link
22. Wang, F.; Gao, W.; Thamphiwatana, S.; Luk, B.T.; Angsantikul, P.; Zhang, Q.; Hu, C-M.; Fang, R.H.; Copp, J.; Pornpattananangkul, D.; Lu, W.; Zhang, L. "Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection", Advanced Materials 2015, 27, 3437-3443. Link | Journal Cover
21. Gao, W.; Fang, R.H.; Thamphiwatana, S.; Luk, B.T.; Li, J.; Angsantikul, P.; Hu, C-M.; Zhang, L. "Modulating antibacterial immunity via bacterial membrane-coated nanoparticles", Nano Letters 2015, 15, 1403-1409. Link
26. Hu, C-M.*; Fang, R.H.*; Wang, K-C.*; Luk, B.; Thamphiwatana, S.; Dehaini, D.; Nguyen, P.; Angsantikul, P.; Wen, C.; Kroll, A.; Carpenter, C.; Ramesh, M.; Qu, V.; Patel, S.; Zhu, J.; Shi, W.; Hofman, F.; Chen, T.; Gao, W; Zhang, K.; Chien, S.; Zhang, L. "Nanoparticle biointerfacing by platelet membrane cloaking", Nature 2015, 526, 118-121. (*Co-first author) Link
25. Zhang, J.; Gao, W.; Fang, R.H.; Dong, A.; Zhang, L. "Synthesis of nanogels via cell membrane-templated polymerization", Small 2015, 11, 4309-4313. Link
24. Fang, R.H.; Luk, B.; Hu, C-M.; Zhang, L. "Engineered nanoparticles mimicking cell membranes for toxin neutralization", Advanced Drug Delivery Reviews 2015, 90, 69-80. Link | Journal Cover
23. Pang, Z.; Hu, C-M. J.; Fang, R. H.; Luk, B. T.; Gao, W.; Wang, F.; Chuluun, E.; Angsantikul, P.; Thamphiwatana, S.; Lu, W.; Jiang, X.; Zhang, L. "Detoxification of organophosphate poisoning using nanoparticle bioscavengers", ACS Nano 2015, 9, 6450-6458. Link
22. Wang, F.; Gao, W.; Thamphiwatana, S.; Luk, B.T.; Angsantikul, P.; Zhang, Q.; Hu, C-M.; Fang, R.H.; Copp, J.; Pornpattananangkul, D.; Lu, W.; Zhang, L. "Hydrogel retaining toxin-absorbing nanosponges for local treatment of methicillin-resistant Staphylococcus aureus infection", Advanced Materials 2015, 27, 3437-3443. Link | Journal Cover
21. Gao, W.; Fang, R.H.; Thamphiwatana, S.; Luk, B.T.; Li, J.; Angsantikul, P.; Hu, C-M.; Zhang, L. "Modulating antibacterial immunity via bacterial membrane-coated nanoparticles", Nano Letters 2015, 15, 1403-1409. Link
2014
20. Copp, J.A.; Fang, R.H.; Luk, B.T.; Hu, C-M.; Gao, W.; Zhang, K.; Zhang, L. "Clearance of pathological antibodies using biomimetic nanoparticles", Proceedings of the National Academy of Sciences 2014, 111, 13481-13486. Link
19. Fang, R.H.; Zhang, L. "Combinatorial nanotherapeutics: Rewiring, then killing, cancer cells", Science Signaling 2014, 7, pe13. Link
18. Fang, R.H.; Hu, C-M.; Luk, B.T.; Gao, W.; Copp, J.A.; Tai, Y.; O’Connor, D.E.; Zhang, L. "Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery", Nano Letters 2014, 14, 2181-2188. Link
17. Luk, B.T.; Hu, C-M.; Fang, R.H.; Dehaini, D.; Carpenter, C.; Gao, W.; Zhang, L. "Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles", Nanoscale 2014, 6, 2730-2737. Link
19. Fang, R.H.; Zhang, L. "Combinatorial nanotherapeutics: Rewiring, then killing, cancer cells", Science Signaling 2014, 7, pe13. Link
18. Fang, R.H.; Hu, C-M.; Luk, B.T.; Gao, W.; Copp, J.A.; Tai, Y.; O’Connor, D.E.; Zhang, L. "Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery", Nano Letters 2014, 14, 2181-2188. Link
17. Luk, B.T.; Hu, C-M.; Fang, R.H.; Dehaini, D.; Carpenter, C.; Gao, W.; Zhang, L. "Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles", Nanoscale 2014, 6, 2730-2737. Link
2013
16. Hu, C-M.; Fang, R.H.; Luk, B.T.; Zhang, L. "Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies", Nanoscale 2013, 6, 65-75. Link
15. Hu, C-M.*; Fang, R.H.*; Luk, B.T.; Zhang, L. "Nanoparticle-detained toxins for safe and effective vaccination", Nature Nanotechnology 2013, 8, 933-938. (*Co-first author) Link
14. Gao, W.; Hu, C-M.; Fang, R.H.; Zhang, L. "Liposome-like nanostructures for drug delivery", Journal of Materials Chemistry B 2013, 1, 6569-6585. Link
13. Fang, R.H.; Hu, C-M.; Chen, K.; Luk, B.T.; Carpenter, C.; Gao, W.; Li, S.; Zhang, D-E.; Lu, W.; Zhang, L. "Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles", Nanoscale 2013, 5, 8884-8888. Link
12. Aryal, S.; Hu, C-M.; Fang, R.H.; Dehaini, D.; Carpenter, C.; Zhang, D-E.; Zhang, L. "Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release", Nanomedicine 2013, 8, 1271-1280. Link
11. Gao, W.; Hu, C-M.; Fang, R.H.; Luk, B.T.; Su, J.; Zhang, L. "Surface functionalization of gold nanoparticles with red blood cell membranes", Advanced Materials 2013, 25, 3549-3553. Link | Journal Cover
10. Hu, C-M.; Fang, R.H.; Copp, J.A.; Luk, B.T.; Zhang, L. "A biomimetic nanosponge that absorbs pore-forming toxins", Nature Nanotechnology 2013, 8, 336-340. Link
9. Hu, C-M.; Fang, R.H.; Luk, B.T.; Chen, K.; Carpenter, C.; Gao, W.; Zhang, K.; Zhang, L. "'Marker-of-self' functionalizaton of nanoscale particles through a top-down cellular membrane coating approach", Nanoscale 2013, 5, 2664-2668. Link
15. Hu, C-M.*; Fang, R.H.*; Luk, B.T.; Zhang, L. "Nanoparticle-detained toxins for safe and effective vaccination", Nature Nanotechnology 2013, 8, 933-938. (*Co-first author) Link
14. Gao, W.; Hu, C-M.; Fang, R.H.; Zhang, L. "Liposome-like nanostructures for drug delivery", Journal of Materials Chemistry B 2013, 1, 6569-6585. Link
13. Fang, R.H.; Hu, C-M.; Chen, K.; Luk, B.T.; Carpenter, C.; Gao, W.; Li, S.; Zhang, D-E.; Lu, W.; Zhang, L. "Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles", Nanoscale 2013, 5, 8884-8888. Link
12. Aryal, S.; Hu, C-M.; Fang, R.H.; Dehaini, D.; Carpenter, C.; Zhang, D-E.; Zhang, L. "Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release", Nanomedicine 2013, 8, 1271-1280. Link
11. Gao, W.; Hu, C-M.; Fang, R.H.; Luk, B.T.; Su, J.; Zhang, L. "Surface functionalization of gold nanoparticles with red blood cell membranes", Advanced Materials 2013, 25, 3549-3553. Link | Journal Cover
10. Hu, C-M.; Fang, R.H.; Copp, J.A.; Luk, B.T.; Zhang, L. "A biomimetic nanosponge that absorbs pore-forming toxins", Nature Nanotechnology 2013, 8, 336-340. Link
9. Hu, C-M.; Fang, R.H.; Luk, B.T.; Chen, K.; Carpenter, C.; Gao, W.; Zhang, K.; Zhang, L. "'Marker-of-self' functionalizaton of nanoscale particles through a top-down cellular membrane coating approach", Nanoscale 2013, 5, 2664-2668. Link
2012
8. Luk, B.T.; Fang, R.H.; Zhang, L. "Lipid- and polymer-based nanostructures for cancer theranostics", Theranostics 2012, 2, 1117-1126. Link
7. Fang, R.H.; Chen, K.; Aryal, S.; Hu, C-M.; Zhang, K.; Zhang, L. "Large-scale synthesis of lipid-polymer hybrid nanoparticles using a multi-inlet vortex reactor", Langmuir 2012, 28, 13824-13829. Link
6. Hu, C-M.; Fang, R.H.; Zhang, L. "Erythrocyte-inspired delivery systems", Advanced Healthcare Materials 2012, 1, 537-547. Link
5. Gu, L; Fang, R.H.; Sailor, M.J.; Park, J.P. “In vivo clearance and toxicity of monodisperse iron oxide nanocrystals”, ACS Nano 2012, 6, 4947-4954. Link
4. Fang, R.H.; Hu, C-M.; Zhang, L. "Nanoparticles disguised as red blood cells to evade the immune system", Expert Opinion on Biological Therapy 2012, 12, 385-389. Link
7. Fang, R.H.; Chen, K.; Aryal, S.; Hu, C-M.; Zhang, K.; Zhang, L. "Large-scale synthesis of lipid-polymer hybrid nanoparticles using a multi-inlet vortex reactor", Langmuir 2012, 28, 13824-13829. Link
6. Hu, C-M.; Fang, R.H.; Zhang, L. "Erythrocyte-inspired delivery systems", Advanced Healthcare Materials 2012, 1, 537-547. Link
5. Gu, L; Fang, R.H.; Sailor, M.J.; Park, J.P. “In vivo clearance and toxicity of monodisperse iron oxide nanocrystals”, ACS Nano 2012, 6, 4947-4954. Link
4. Fang, R.H.; Hu, C-M.; Zhang, L. "Nanoparticles disguised as red blood cells to evade the immune system", Expert Opinion on Biological Therapy 2012, 12, 385-389. Link
2011
3. Hu, C-M.; Zhang, L.; Aryal, S.; Cheung, C.; Fang, R.H.; Zhang, L. "Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform", Proceedings of the National Academy of Sciences 2011, 1, 106-112. Link
2. Fang, R.H.; Zhang, L. "Dispersion-based methods for the engineering and manufacture of polymeric nanoparticles for drug delivery applications", Journal of Nanoengineering and Nanomanufacturing 2011, 108, 10980-10985. Link
2. Fang, R.H.; Zhang, L. "Dispersion-based methods for the engineering and manufacture of polymeric nanoparticles for drug delivery applications", Journal of Nanoengineering and Nanomanufacturing 2011, 108, 10980-10985. Link
2010
1. Fang, R.H.; Aryal, S.; Hu, C-M; Zhang, L. “Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method", Langmuir 2010, 26, 16958-16962. Link